Brand name: methotrexate
Generic name: amethopterin, MTX, Emthexate, Methoblastin, Rheumatrex

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It works like folic acid in the body, which helps to reduce the action and toxic effects of folic acid antagonists (eg, methotrexate). Leucovorin may limit methotrexate action on normal cells by competing with methotrexate for the same transport processes into the cell. It is recommended that duration of leucovorin administration in these patients be based on determination of plasma methotrexate concentrations. Pregnant women with psoriasis or rheumatoid arthritis should not receive methotrexate (See CONTRAINDICATIONS). Necrotizing fasciitis resulting in death has been reported in a 54-year-old man with rheumatoid arthritis receiving infliximab every 8 weeks along with intramuscular methotrexate weekly dosage. MANAGEMENT: The use of methotrexate in combination with other potentially hepatotoxic agents (e. He was treated for RA with infliximab (3 mg/kg) for 3 years, as well as methotrexate (20 mg/week), and corticosteroids. Cutaneous lesions partially remitted following infliximab discontinuation and methotrexate treatment.

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